MyBioSource.com's RBP3 Antibody (Center) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The RBP3 Antibody (Center) was generated using D10S64, and RBP3 as the antigen and it reacts with Human, and Mouse.
Description
Interphotoreceptor retinol-binding protein is a large
glycoprotein known to bind retinoids and found primarily in the
interphotoreceptor matrix of the retina between the retinal pigment
epithelium and the photoreceptor cells. It is thought to transport
retinoids between the retinal pigment epithelium and the
photoreceptors, a critical role in the visual process.The human
IRBP gene is approximately 9.5 kbp in length and consists of four
exons separated by three introns. The introns are 1.6-1.9 kbp long.
The gene is transcribed by photoreceptor and retinoblastoma cells
into an approximately 4.3-kilobase mRNA that is translated and
processed into a glycosylated protein of 135,000 Da. The amino acid
sequence of human IRBP can be divided into four contiguous homology
domains with 33-38% identity, suggesting a series of gene
duplication events. In the gene, the boundaries of these domains
are not defined by exon-intron junctions, as might have been
expected. The first three homology domains and part of the fourth
are all encoded by the first large exon, which is 3,180 base pairs
long. The remainder of the fourth domain is encoded in the last
three exons, which are 191, 143, and approximately 740 base pairs
long, respectively